Pharmacology

✅Goodman & Gilman's – Pharmacological basis of therapeutics 

                                                      

       

Standard book in pharmacology by renowned pharmacologists. Considered as the gold standard of pharmacology. Best in concept and accurate information while correlating with physiology, pathology and medicine aspects. Explained with colored illustrations and with drug action and their effects on the body. Best book for a crystal clear understanding of the subject and is used by postgraduates and practicing professionals as well.

✅KD Tripathi – Essentials of pharmacology

                                                     

       

Covers all the essential concepts in pharmacology and explained them in detail with supporting flow charts and diagrams. Has drug classification with pictures and all recent drugs are included. Each disease is prescribed with reference to other standard books and is according to evidence-based medicine. Indian specific disease and their treatment are focused along with some new chapters.

✅Lippincott’s illustrated reviews pharmacology

                                                     

       

Another good book in pharmacology that explains concepts comprehensively with numerous flowcharts, tables, and diagrams. All the concepts are integrated with other subjects in medicine and new topics are included. Explanations are very clear with reference. Interaction of drugs is highlighted in boxes to make students understand the importance of the action. Each chapter ends with questions of all formats to make students ready for their exams.

✅Rang and dale’s Pharmacology 

                                                       

       

A comprehensive book on pharmacology explained core concepts and imparted clinical knowledge to students physicians. Up to date and thoroughly revised concepts. All the recent studies and newer drugs are added in the new edition. Concepts are dealt with up till the molecular level for students aspiring to learn in-depth and understand everything about the respective drug.

✅Shanbhag Pharmacology 

                                                     

       

A comprehensive and concise book in pharmacology. Often preferred by students for its unique concise content and is written in simple language which makes it the best book for first reading or revising prior to exams. All the concepts are explained to what is required and with the help of flowcharts and tables. All the essential and clinical aspects of drugs are also included along with the respective body systems.

Science  has advanced immeasurably in the 20th and

21st centuries, as is evident in almost everything

around us.

The vehicles we use to fly around the world

and go to space, the comforts of the modern

home, and the internet you’re using right

now to watch this video.

But one of the most impressive areas of scientific

advancement is that of modern medicine.

With the astounding progress made in chemistry,

biochemistry, and biology over the last century

or so, we have been able to go from complete

darkness when it comes to the cause of disease,

to understanding precise causes for almost

every condition in existence.

As it happens, these causes always have their

basis on the molecular level, whether genetic,

pathogenic, or otherwise.

And through our modern understanding of the

molecular world, we have sequenced the human

genome, we have identified and characterized

thousands of bacteria and viruses, and we

have gained a sophisticated understanding

of the biochemistry that regulates all of

our cells, organs, and metabolic processes.

One of the crowning achievements of this progress

is our understanding of drugs.

Perhaps we are able to ascertain that the

cause of a particular disease is a specific

microorganism, like a bacterium.

By understanding all of the biochemical processes

in that bacterium, we can develop a strategy,

perhaps introducing a molecule that binds

to the active site of a bacterial enzyme that

is critical to its survival, preventing the

enzyme from performing its function and thus

killing those bacterial cells.

We can call this process inhibition.

Perhaps the cause of a disease is simply an

imbalance in certain signaling molecules in

the body, such as hormones or neurotransmitters.

Again, if we can identify the precise cause,

we can develop a molecule that can be introduced

to the body that will help regulate that activity,

either by interacting with some protein in

a specific way, or any number of other strategies.

Whatever the case may be, a molecule of this

nature will have a highly specific therapeutic

effect, and such a molecule would therefore

be called a drug.

A drug is a substance which has a physiological

effect when introduced to the body, other

than substances of typical nutritional value.

It is true that certain drugs are frequently

ingested by many people.

These would be things like caffeine, alcohol,

and other commonplace substances.

While those will be of interest to us in this

series as well, far more focus will be placed

on substances like that small molecule that

was able to inhibit that bacterial enzyme,

or regulate neurotransmitter levels, or perform

some other biochemical function.

Perhaps this small molecule exists in nature,

whether in animals, plants, or microorganisms.

We would call these natural products.

Perhaps it doesn’t exist, and we have to

conceive of it and synthesize it ourselves

in a laboratory.

Perhaps it isn’t a small molecule at all,

but rather a larger macromolecule like an

antibody, sometimes referred to as biologics.

Whatever the case may be, we really want to

understand drugs.

We want to know about a wide variety of drugs,

as there are thousands of them.

We want to know precisely what they do in

the body, and we want to know how they do

these things on the molecular level.

We want to know their applications, and we

want to know if and when they are safe to use.

All of this is precisely the domain of pharmacology,

which is the branch of medicine concerned

with the uses, effects, and mechanisms of

action for any and all drugs.

Of course, to understand how drugs interact

with the body, there is a tremendous amount

of prerequisite knowledge that must be covered.

We have to know a lot about small molecules,

because most drugs are small molecules.

That means we have to understand general chemistry

and organic chemistry.

We also have to know a lot about the biomolecules

that drugs will interact with, like proteins

and nucleic acids.

That means we have to understand biochemistry.

We have to know some things about cell structure

and cellular activity, because drugs may directly

influence cell division, metabolism, or any

number of other complex cellular processes.

That means we have to understand biology.

We have to know a decent amount regarding

the structure and function of all the components

of the human body, such as the brain, heart,

and the rest of the organs, as well as the

nervous system, immune system, circulatory

system, and other systems, because many diseases

are associated closely with one of these organs

or systems, and affect their regular function.

Drugs also have to travel through the body

to reach a particular target and produce the

desired response.

All of this means that we have to understand

human anatomy and physiology.

We may even have to know some things about

specific microorganisms called pathogens,

as these are the ones that cause disease in humans.

That means we have to understand microbiology.

While key concepts in these disciplines may

be briefly reiterated, for the most part,

basic knowledge in the above subjects will

be assumed throughout this series.

But the good news is that I have playlists

in every single one of the subjects we just

mentioned, that you can watch through to completion

if you want to truly comprehend this pharmacology

content, or you can go back and watch just

a few videos as necessary if gaps in your

understanding should arise.

When particularly appropriate, I will link

to videos in those playlists using cards that

show up in the upper right corner of the screen,

and these will take you to a video that explains

in more depth a concept that is being utilized

at that moment.

With enough background knowledge, it will

be possible to comprehend the effects a drug

will have in the body, and the various factors

that influence a drug’s bioactivity.

This also means we won’t fall for any medicine-related

hoaxes, because fraudulent treatments that

are totally inconsistent with the molecular

world become very easy to spot.

So if you think you’re ready to dive into

this topic, let’s learn about some drugs.

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